prion protein — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TP2284	Prion Protein 106-126 (human)		Others
	Prion peptide fragment that exhibits neurotoxicity		Others
T9174	Icerguastat	Sephin 1,lcerguastat,IFB-088	Phosphatase
	Icerguastat (IFB-088) is a selective inhibitor of holophosphatase. Sephin1 safely and selectively inhibited a regulatory subunit of protein phosphatase 1 in vivo.		Phosphatase
T23450	TCS PrP Inhibitor 13	5-(4-Nitrophenyl)-2-Phenyl-4H-Pyrazol-3-One	Others
	TCS PrP Inhibitor 13 (5-(4-Nitrophenyl)-2-Phenyl-4H-Pyrazol-3-One) is an antiprion agent inhibiting protease-resistant prion protein (PrP-res) accumulation.		Others
T12563	PrPSc-IN-1		Others
	PrPSc-IN-1 is a fluorescent probe, binds to the misfolded protein PrPSc, inhibits its accumulation(IC50 of 1.6 μM), with anti-prion activity.		Others
T27314	Fe-TMPyP
	Fe-TMPyP binds to the prion protein PrP and inhibits misfolding. Fe-TMPyP is also a peroxynitrite decomposition catalyst.
T68763	PQQ-TME
	PQQ-TME exhibits greater inhibitory activity against fibrillation of α-synuclein, Aβ1-42, and prion protein than PQQ. PQQ-TME also has twice the BBB permeability than PQQ in vitro.
T23210	Quinacrine (dihydrochloride hydrate)	Quinacrine (hydrochloride hydrate) (83-89-6 free base)	Others
	Quinacrine is a compound that is commonly used as an anti-protozoal agent. It inhibits voltage-dependent sodium channels (IC50: 3.3 μM） and suppresses aldehyde oxidase (IC50: 3.3 μM). Quinacrine prevents misfolding of pr...		Others
T81312	Ralzapastotug	AB-308
	Ralzapastotug (AB-308) is a monoclonal antibody that targets amino acids 106-126 of the prion protein PrP^C[1].
T62105	NT219	NT-219	STAT
	NT219 is a dual inhibitor of insulin receptor substrate 1/2 (IRS1/2) and STAT3, enhances the aggregation of misfolded prion protein NT219 affects the levels of certain molecular chaperones and inhibits STAT3 phosphorylat...		STAT
T79038	Tau protein aggregation-IN-1
	Tau Protein Aggregation-IN-1 (Compound 0c) serves as an inhibitor of Tau protein aggregation, applicable in research related to protein folding disorders including Alzheimer's disease, dementia, Parkinson's disease, Hunt...
T73416	BiCAPPA
	BiCAPPA, a pioneering bivalent antiprion ligand, effectively reduces the infectious conformational form of prion protein (PrP Sc) in scrapie-infected cells, achieving this at a concentration (EC 50) of 0.32 μM.
T38187	6-Aminophenanthridine
	6-Aminophenanthridine is an antiprion agent. It inhibits prion formation in yeast- and mammalian-based screening assays when used alone and, to a greater extent, when used in combination with the α2-adrenergic receptor a...

Compounds

Prion Protein 106-126 (human)

TP2284

Synonym: Sephin 1,lcerguastat,IFB-088

Target: Phosphatase

TCS PrP Inhibitor 13

T23450

Synonym: 5-(4-Nitrophenyl)-2-Phenyl-4H-Pyrazol-3-One

Quinacrine (dihydrochloride hydrate)

T23210

Synonym: Quinacrine (hydrochloride hydrate) (83-89-6 free base)

Tau protein aggregation-IN-1

6-Aminophenanthridine

T38187

Synonym:

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPK-00775	PRNP/Prion Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	Prion protein gene (PRNP) variants determine the susceptibility of humans, sheep and mice to prion diseases, whereas polymorphisms in the open reading frame (ORF) of bovine PRNP seem to be unrelated to the incidence of b...
TMPY-03842	PRNP/Prion Protein Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Prion protein (PRNP) gene is well known for affecting mammal transmissible spongiform encephalopathies (TSE), and is also reported to regulate phenotypic traits (e.g. growth traits) in healthy ruminants. PRNP is fundamen...
TMPY-00350	Doppel/PRND Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Doppel/PRND Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.9 kDa and the accession number is Q9UKY0.
TMPY-00347	Doppel/PRND Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Doppel/PRND Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 41.2 kDa and the accession number is Q9UKY0.
TMPJ-01368	GPC1 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Glypican-1 is a cell membrane protein and belongs to the glypican family. The protein may act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfa...